胞磷胆碱钠联合奥拉西坦治疗脑出血的临床疗效

Effect of Citicoline Sodium Combined with Oxiracetam in treatment of Cerebral Hemorrhage

目的观察胞磷胆碱钠联合奥拉西坦治疗脑出血的临床疗效。方法选取2015年5月—2017年6月桂林医学院第二附属医院神经内科收治的脑出血患者364例,随机分为对照组175例和试验组189例。两组患者均给予基础治疗,对照组患者给予胞磷胆碱钠治疗,试验组患者给予胞磷胆碱钠联合奥拉西坦治疗,两组患者均连续治疗3周。比较两组患者治疗后1周、2周、3周血肿量,治疗3周后简易智力状态检查量表(MMSE)评分、Barthel指数(BI)评分及临床疗效。结果治疗后1周、2周、3周试验组患者血肿量少于对照组,治疗后MMSE评分和BI评分均高于对照组(P<0.05)。试验组患者临床疗效优于对照组(P<0.05)。结论胞磷胆碱钠联合奥拉西坦治疗脑出血的疗效确切,能有效减少血肿量,改善患者认知功能,提高生活质量。

Objective To investigate the effect of citicoline sodium combined with oxiracetam in treatment of cerebral hemorrhage.Methods A total of364patients with cerebral hemorrhage were selected in the Second Affiliated Hospital of Guilin Medical College,from May2015to June2017,they were randomly divided into control group(n=175)and experimental group(n=189).Two groups of patients were given basic treatment,the control group were treated with citicoline sodium,the experimental group were treated with citicoline sodium combined with oxiracetam,all were treated for3weeks.The volume of hematoma at1,2,and3weeks after treatment,MMSE score,BI score and clinical effects were compared between two groups.Results After treatment,the experimental group compared with the control group,the amount of intracranial hematoma was significantly less,MMSE and BI scores were significantly higher,the treatment efficiency was significantly higher,the difference between groups was significant,comparable(P<0.05).Conclusion The effect of citicoline sodium combined with oxiracetam in the treatment of cerebral hemorrhage is accurate,tt can effectively reduce the volume of hematoma,improve the cognitive function and quality of life.