近视程度与扫描激光偏振仪测量神经纤维层厚度相关性分析

Correlation Analysis of the Degree of Myopia and the Retinal Nerve Fiber Layer Thickness Measured by Scanning Laser Polarimetry

目的:应用扫描激光偏振仪(SLP)(GDx ECC)测量近视眼患者视网膜神经纤维层(RNFL)厚度,探讨近视眼RNFL厚度与等效球镜度数和眼轴长度的关系。方法:采用横断面研究。将近视眼患者147例(147眼)根据等效球镜(SE)度数分为3组,其中低度近视眼组26例26眼(-0.5 D≥SE>-3.0 D),中度近视眼组64例64眼(-3.0 D≥SE>-6.0D)和高度近视眼组57例57眼(-6.0 D≥SE≥-13.0 D)。应用SLP测量近视眼患者视乳头周围(TSNIT)RNFL厚度,采用单因素方差分析比较3组RNFL厚度,用偏相关分析来分析RNFL厚度与等效球镜度数、眼轴长度的相关性。结果:3组TSNIT平均RNFL厚度、上方和下方的平均RNFL厚度、TSNIT标准差和神经纤维指数(NFI)差异均无统计学意义。TSNIT平均RNFL厚度、上方和下方的平均RNFL厚度、TSNIT标准差和NFI与等效球镜度数、眼轴长度均无相关性。结论:应用SLP测得近视眼患者的TSNIT平均RNFL厚度、上方和下方的平均RNFL厚度、TSNIT标准差和NFI与等效球镜度数及眼轴长度无显著相关性,SLP测量的RNFL参数可能作为近视眼合并青光眼患者早期诊断的重要参考指标。

Objective:To measure the changes of retinal nerve fiber layer(RNFL)thickness by scanning laser polarimetry(SLP,GDx ECC)in myopic individuals and to explore the correlation among RNFL thickness and spherical equivalent refraction(SE)and axis length of myopia.Methods:Totally 147 eyes of 147 healthy Chinese myopic individuals were enrolled and were divided into low myopia group(n=26,-0.5 D≥SE>-3.0 D),moderate myopia group(n=64,-3.0 D≥SE>-6.0 D),and high myopia group(n=57,-6.0 D≥SE≥-13.0 D)by their SE.The thickness of RNFL including TSNIT,superior,inferior and TSNIT standard deviation and NFI were measured by SLP.The difference of RNFL thicknesses in three groups were compared by ANOVA.Correlations between RNFL thickness and axial length/SE were evaluated by partial correlation analysis.Results:There was no significant difference in above indicators in three groups.No significant correlation was detected between axial length/SE and overall RNFL thickness measured by SLP.Conclusions:Overall RNFL thickness does not vary with myopic SE or axial length measured by SLP.RNFL thickness measurements may be a useful parameter to assess and monitor glaucoma damage in myopic individuals.