中医辨证施治对肾病综合征的疗效及对免疫球蛋白、载脂蛋白及补体水平的影响

Effect of Traditional Chinese Medicinesyndrome differentiation treatment on nephrotic syndrome and levels of immunoglobulin,apolipoprotein and complemen

目的探讨中医辨证施治对肾病综合征的疗效及对免疫球蛋白(Ig)、载脂蛋白(Apo)及补体(C)水平的影响。方法前瞻性选取2014年1月至2016年1月期间收治的肾病综合征患者80例作为研究对象,随机分为两组,每组40例。对照组患者给予常规西药治疗,观察组患者给予中医辨证施治疗。比较两组患者临床疗效、Ig、Apo及C含量、不良反应发生率和复发率。结果观察组患者临床总有效率(95.00%)明显高于对照组(80.00%),不良反应发生率(22.50%)明显低于对照组(67.50%),差异有统计学意义(P<0.05)。观察组患者IgG、C3和C4水平明显高于对照组,IgE、IgM、ApoA1和ApoB水平明显低于对照组,差异有统计学意义(P<0.05)。对照组患者中有6例(15.00%)复发,观察组患者中无复发,观察组复发率明显低于对照组,差异有统计学意义(P<0.05)。结论中医辨证施治疗肾病综合征患者疗效确切,能显著提高患者机体免疫力,降低不良反应发生率和复发率,且安全可靠,值得临床推广使用。

Objective To investigate the effect of TCM syndrome differentiation and treatment on nephrotic syndrome and the levels of immunoglobulin(Ig),apolipoprotein(Apo)and complement(C).Methods Eighty patients with nephrotic syndrome admitted from January 2015 to January 2016 were selected and randomly divided into two groups,40 cases in each group.Control group of patients were given conventional Western medicine,observation group patients were given TCM syndrome differentiation treatment.Clinical efficacy,levels of IgA,Apo and C content,incidence of adverse reactions and relapse rate were compared between the two groups.Results The total effective rate of the observation group(95.00%)was significantly higher than that of the control group(80.00%),the incidence of adverse reactions(22.50%)was significantly lower than that in the control group(67.50%),the difference was statistically significant(P<0.05).The levels of IgG,C3 and C4 in the observation group were significantly higher than those in the control group,while the levels of IgE,IgM,ApoA1 and ApoB in the observation group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).There were 6 patients(15.00%)in the control group relapsed,and there was no recurrence in the observation group,the difference was statistically significant(P<0.05).Conclusion Curative effect of TCM syndrome differentiation and treatment of patients with nephrotic syndrome is exact,and can significantly improve the patient's immune system,reduce the incidence of adverse reactions and recurrence rates,and is safe and reliable,it is worth clinical promoting.