焦虑障碍患者的客观睡眠与临床特征相关性研究

Correlation between objective sleep and clinical features in patients with anxiety disorders

目的探讨焦虑障碍患者睡眠状况的一般特点以及与临床症状之间的关系。方法运用病例对照研究方法分析32例焦虑障碍患者和30例健康对照人群的整夜多导睡眠图差异,并与临床症状进行相关分析。结果与健康对照组比较,焦虑障碍患者表现为睡眠效率下降(P<0.05),睡眠潜伏期时间延长(P<0.05),非快动眼睡眠阶段百分比增加(P<0.01),快动眼睡眠阶段时限减少(P<0.01),以及快动眼睡眠阶段百分比下降(P<0.01)。非快眼动睡眠第Ⅱ期睡眠百分比与汉密尔顿焦虑量表总分成正相关(r=0.356,P<0.05),与精神焦虑因子分成正相关(r=0.448,P<0.05)。结论焦虑障碍存在多项客观睡眠指标异常,且临床焦虑症状程度与客观睡眠指标具有相关性。因此,进一步结合神经生化、神经影像学等深入研究,对于探讨该病的病理机制具有一定价值。

Objective To explore the general characteristics of sleep in anxiety disorder patients and the relationship between sleep status and clinical symptoms.Methods A case-control study was conducted to analyze the difference in polysomnography between32patients with anxiety disorders and30normal controls,and to analyze the clinical symptoms.Results Compared with normal control group,patients with anxiety exhibited disorders decreased sleep efficiency(P<0.05),prolonged sleep latency(P<0.05),non REM sleep stages increased(P<0.01),REM sleep stage time(P<0.01),and reduced the REM sleep stage percentage(P<0.01).The percentage of II sleep in REM sleep was positively related to the Hamilton Anxiety Scale(r=0.356,P<0.05),and was positively related to mental anxiety factors(r=0.448,P<0.05).Conclusions There are many objective sleep indexes in anxiety disorder,and the degree of clinical anxiety is correlated with objective sleep index.Therefore,it is valuable to further investigate the pathological mechanism of the disease by further studying the biochemistry,neuroimaging and so on.