962例C13呼气试验幽门螺杆菌检测结果临床分析

Clinical analysis of the detection of Helicobacter pylori in 962 patients with C13 expiratory test

目的通过分析宝鸡市中心医院消化内科试验室C13呼气试验幽门螺杆菌(Hp)检测结果,探讨宝鸡地区人群Hp感染的流行情况。方法回顾性分析2015年5月至2015年10月来我试验室进行C13呼气试验检查的962例患者的临床资料,按年龄、性别、病种分别统计患者的Hp感染情况,并统计病理组织学检查Hp阴性患者行C13呼气试验检查的结果。结果接受C13呼气试验检查的962例患者中,Hp阳性患者699例,Hp感染率为72.7%。青年人组及中老年人组患者Hp感染率明显高于未成年人组(P<0.05);青年人组及中老年人组患者Hp感染率比较,差异无统计学意义(P>0.05)。男性患者Hp感染率与女性患者比较,差异无统计学意义(P>0.05)。功能性消化不良的Hp感染率明显低于胃穿孔术后及胃癌、胃食管反流病及贲门疾病(炎症、溃疡、息肉或癌)、胃息肉、慢性胃炎、消化性溃疡的Hp感染率(P<0.05);其他各疾病Hp感染率比较,差异无统计学意义(P>0.05)。不同种类的消化性溃疡Hp感染率比较,差异无统计学意义(P>0.05)。病理组织学检查为阴性的199例患者中,143例(71.9%)行C13呼气试验呈阳性。结论宝鸡市地区不同性别患者Hp感染率无明显差异,感染率随年龄增加呈增高趋势。与Hp感染相关的疾病中除胃食管反流病、贲门疾病患者的Hp感染率高于其他研究外,慢性胃炎、消化性溃疡、术后胃、胃癌及功能性消化不良等的本地区的感染率基本与国内外研究一致。

Objective To investigate the prevalence of Helicobacter pylori(Hp)infection in the population of Baoji through the results of Hp detection in the laboratory of gastroenterology department in Baoji Central Hospital.Methods The clinical data of 962 patients who received C13 expiratory test from May 2015 to October 2015 were retrospectively analyzed.Hp infection was counted according to age,sex and disease type,and the results of C13 expiratory test were analyzed in patients with Hp negative by histopathology.Results In 962 patients with C13 expiratory test,there were 699 cases with Hp positive,and the Hp infection rate was 72.7%.The Hp infection rates in the young group and the middle aged group were higher than that in the minor group(P<0.05),but there was no significant difference in the Hp infection rate between the young group and the middle aged group(P>0.05).There was no significant difference in Hp infection rate between male and female patients(P>0.05).The Hp infection rate in patients with functional dyspepsia was lower than that in patients with gastric perforation and gastric cancer,gastroesophageal reflux disease and cardia disease(inflammation,ulcer,polyp or cancer),gastric polyp,chronic gastritis and peptic ulcer(P<0.05),but there was no significant difference in Hp infection rate among other diseases(P>0.05).There was no significant sifference in Hp infection rates of different types of peptic ulcer(P>0.05).Of 199 cases with negative histopathology,143 cases(71.9%)were positive for C13 expiratory test.Conclusion There is no significant difference between different genders in Hp infection rate in Baoji,but that increased with the increase of age.The Hp infection rate in patients with HP related diseases,except gastroesophageal reflux disease and cardiac disease are higher than that in other studies,the infection rate of chronic gastritis,peptic ulcer,postoperative stomach,gastric cancer and functional dyspepsia are basically consistent with domestic and foreign studies.