大剂量甲钴胺治疗脊髓亚急性联合变性40例临床分析

Clinical analysis of high-dose mecobalamin in the treatment of 40 patients with subacute combined degeneration of the spinal cord

目的观察大剂量甲钴胺治疗脊髓亚急性联合变性的临床效果。方法 80例脊髄亚急性联合变性患者随机分为对照组和观察组,各40例,对照组采用常规治疗,观察组在此基础上给予大剂量甲钴胺治疗。比较两组患者的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,两组神经功能评分均显著低于治疗前,观察组低于对照组(P<0.05)。两组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。结论在常规治疗的基础上加用大剂量甲钴胺治疗脊髓亚急性联合变性的临床效果显著,值得临床推广应用。

Objective To high-dose of mecobalamin in the treatment of subacute combined degeneration of spinal cord.Methods Eighty patients with spinal cord subacute combined degeneration were randomly divided into control group and observation group,with 40 cases in each group.The control group was given conventional treatment,and the observation group was given high-dose methylcobalamin treatment on the basis of the control group.The treatment effects of the two groups were compared.Results The total effective rate in the observation group was higher than that in the control group(P<0.05).The scores of neurological function after treatment were significantly lower than those before treatment,and those in the observation group were significantly lower than the control group(P<0.05).There was no significant difference in the incidences of adverse reactions between the two groups(P>0.05).Conclusion The high-dose of mecobalamin based on the conventional treatment in the treatment of subacute combined degeneration of spinal cord has remarkable clinical effect,which is worthy of clinical application.