熊去氧胆酸联合二甲双胍对非酒精性脂肪肝患者肝功能的影响

Influence of ursodeoxycholic acid combined with metformin on the liver function in patients with non-alcoholic fatty liver disease

目的观察熊去氧胆酸联合二甲双胍对非酒精性脂肪肝(NAFLD)患者肝功能的影响。方法选取我院2016年3月至2017年1月收治的NAFLD患者118例为研究对象,随机分为对照组和观察组,各59例。两组均进行对症治疗,对照组给予二甲双胍治疗,观察组在其基础上联合熊去氧胆酸治疗。比较两组的治疗效果。结果治疗后,观察组患者的ALT、GGT、AST水平低于对照组与治疗前(P<0.05);治疗后,观察组患者的TC、LDL-C、TG水平降低且低于对照组,HDL-C水平升高且高于对照组(P<0.05);观察组患者的治疗总有效率高于对照组(P<0.05)。两组患者均无严重的不良反应。结论熊去氧胆酸联合二甲双胍治疗NAFLD效果显著,可有效改善患者肝功能及血脂,减少肝脏脂肪堆积,且临床用药安全性较高。

Objective To observe the influence of ursodeoxycholic acid combined with metformin on the liver function in patients with non-alcoholic fatty liver disease(NAFLD).Methods A total of 118 patients with NAFLD were selected from March 2016 to January 2017 in our hospital,and they were randomly divided into control group and observation group,with 59 cases in each group.The two groups were treated with symptomatic treatment,then the control group was given metformin treatment;on the basis,the observation group was combined with ursodeoxycholic acid.The treatment effects of two groups were compared.Results After treatment,the levels of ALT,GGT and AST in the observation group were lower than those in the control group and before tretment(P<0.05).After treatment,the levels of TC,LD L-C and TG in the observation group were lower than those in the control group and before tretment,and the level of H D L-C in the observation group was higher than those in the control group and before tretment(P<0.05).The total effective rate of the observation group was higher than that of the control group(P<0.05).No serious adverse reactions occurred in both groups.Conclusion Ursodeoxycholic acid combined with metformin has remarkable effect on NAFLD,which can improve the liver function and blood lipid,decrease hepatic fat accumulation,with high drug safety