复方多粘菌素B软膏联合丙酸氟替卡松乳膏治疗湿疹的临床疗效及作用机制

Clinical efficacy and mechanism of compound polymyxin B ointment combined with fluticasone propionate cream in the treatment of eczema

目的探讨分析复方多粘菌素B软膏联合丙酸氟替卡松乳膏治疗湿疹的临床疗效及作用机制。方法将我院在2015年2月至2016年12月收治的98例湿疹患者纳入研究,根据不同的治疗方式分为观察组与对照组,每组49例。对照组患者给予单纯的丙酸氟替卡松乳膏外搽皮疹处,1次/d;观察组采取复方多粘菌素B软膏联合丙酸氟替卡松乳膏交替外涂于患处,2次/d。观察记录两组患者治疗后第7、15天的临床疗效及用药不良反应情况。结果在治疗后第7天,观察组总有效率(75.51%)与对照组(73.47%)比较,差异无统计学意义(P>0.05);在治疗后第15天,观察组总有效率(93.88%)明显高于对照组(77.55%)(P<0.05)。两组患者均未出现严重的不良反应,观察组不良反应总发生率(10.20%)与对照组(16.33%)比较,差异无统计学意义(P>0.05)。结论相比单纯使用丙酸氟替卡松乳膏治疗湿疹患者,运用复方多粘菌素B软膏联合丙酸氟替卡松乳膏交替用药疗效更佳,且不良反应少。

Objective To investigate the clinical efficacy and mechanism of compound polymyxin B ointment combined with fluticasone propionate cream in the treatment of eczema.Methods Ninety-eight patients with eczema in our hospital from February 2015 to December 2016 were selected.Patients were divided into the observation group and the control group according to different treatment methods,with 49 cases in each group.The control group were treated with pure fluticasone propionate cream skin rash,1 time per day;and the observation group were treated with compound polymyxin B ointment combined with fluticasone propionate cream,2 times per day.The clinical efficacy and adverse drug reactions of the two groups were recorded after 7 th and 5th days of treatment.Results At 7 th day after treatment,the total efficiency in the observation group(75.51%)had no statistical significance with that of the control group(73.47%)(P>0.05).At 15th after treatment,the total efficiency of the observation group(93.88%)was significantly higher than that in the control group(77.55%)(P<0.05).No serious adverse reactions occurred in the two groups,there was no significant difference in the total incidence rate of adverse reactions between the control group(10.20%)and the observation group(16.33%)(P>0.05).Conclusion Compared with fluticasone propionate cream in patients with eczema,compound polymyxin B ointment combined with fluticasone propionate cream alternately has better curative effect,with less adverse reactions.