肝纤维化指标和血清铁蛋白在肥胖儿童非酒精性脂肪肝病中的临床意义

Clinical significance of hepatic fibrosis indexes and serum ferritin in nonalcoholic fatty liver disease in obese children

目的探讨肝纤维化指标和血清铁蛋白(SF)在肥胖儿童非酒精性脂肪肝病(NAFLD)中的临床意义。方法选取我院收治的肥胖患儿200例,包括单纯性肥胖患儿(SOC)48例,单纯性非酒精性脂肪肝患儿(SNAFL)94例,NAFLD患儿58例;同时,以来我院体检的健康儿童60例作为对照组。检测并比较各组肝纤维化指标和SF水平。结果与对照组比较,SNAFL组及NAFLD组的肝纤维化各指标、SF及肝转氨酶水平明显更高(P<0.05);与对照组比较,SOC组患儿除SF及ALT外,其余各指标水平均明显更高(P<0.05)。与SOC组比较,SNAFL组及NAFLD组患儿的HA、PCⅢ、SF、ALT及AST水平明显更高(P<0.05)。与SNAFL组比较,NAFLD组患儿的PCⅢ、SF、ALT及AST水平明显更高(P<0.05)。肥胖儿童的SF水平与PCⅢ、ALT及AST水平相关,PCⅢ水平与ALT及AST水平相关(P<0.05)。结论肝纤维化血清学指标与NAFLD进展密切相关;SF是反应患儿肝损伤情况的重要指标,与儿童NAFLD发生、发展显著相关。

Objective To investigate the clinical significance of serum indexes of liver fibrosis and serum ferritin(SF)in nonalcoholic fatty liver disease(NAFLD)in obese children.Methods Two hundred obese children admitted in our hospital were selected,including 48 simple obese(SOC)children,94 simple nonalcoholic fatty liver disease(SNAFL)children and 58 NAFLD children,and they were enrolled as SOC group,SNAFL group and NAFLD respectively.Another 60 healthy children received physical examination in our hospital were selected as the control group.The serum indexes of liver fibrosis and SF level were detected and compared among the groups.Results Compared with the control group,the levels of serum indexes of liver fibrosis,SF and liver transaminase in the SNAFL group and NAFLD group were higher(P<0.05),and those of the SOC group were higher besides SF and ALT(P<0.05).Compared with the SOC group,the levels of HA,P C H,SF,ALT and AST in the SNAFL group and NAFLD group were higher(P<0.05).Compared with the SNAFL group,the levels of PC芋,SF,ALT and AST in the NAFLD group were higher(P<0.05).The level of SF was correlated with the levels of PC芋,ALT and AST in obese children,and the level of PC芋was correlated with the levels of ALT and AST(P<0.05).Conclusion The serum indexes of liver fibrosis are closely related to the development of NAFLD.The SF is an important index of liver injury in children,and it is significantly correlated with the occurrence and development of NAFLD in children.