沙美特罗替卡松联合孟鲁司特钠治疗小儿哮喘急性发作的临床疗效

Clinical efficacy of salmeterol fluticasone in combination with montelukast sodium in the treatment of acute attack infantile asthma

目的分析美特罗替卡松联合孟鲁司特钠治疗小儿急性哮喘的临床疗效。方法本次研究所选取研究对象为陕西省子长县人民医院儿科接收急性哮喘疾病患儿80例(2014年1月1日至2017年1月1日),按照随机抽选的方式,将40例仅采用孟鲁司特钠治疗的患儿记为A组,40例采用沙美特罗替卡松联合孟鲁司特钠治疗的患儿记为B组。对比分析两组患儿的治疗效果。结果 B组患者的治疗总有效率达95.00%(38/40),A组患者治疗总有效率达75.00%(30/40);B组患者治疗总有效率高于A组(P<0.05)。B组出现1例嗜睡,不良反应总发生率为2.50%(1/40);A组出现3例嗜睡,2例头晕,1例腹痛,不良反应总发生率为15.00%(6/40);两组患者的不良发应总发生率比较,差异显著(X^2=3.914,P<0.05)。结论美特罗替卡松联合孟鲁司特钠治疗小儿急性哮喘,临床效果显著,在临床上具有可行性。

Objective To analyze and observe the clinical effect of salmeterol fluticasone in combination with montelukast sodium in the treatment of acute attack infantile asthma. Methods The research objects in this study were 80 cases of children with acute asthma in the pediatrics department of the People's Hospital of Zichang County(January 1, 2014 to January 1, 2017). According to the method of random selection, 40 children treated with montelukast sodium alone were enrolled as the group A, and 40 children treated with salmeterol fluticasone plus montelukast sodium were assigned as the group B. The treatment effects of the two groups were comparatively analyzed. Results The total effective rate was 95.00%(38/40) in the group B, the total effective rate in the group A was 75.00%(30/40); the total effective rate in the group B was higher than that in the group A(P<0.05). There was 1 case of drowsiness in the group B, and the total incidence of adverse reactions was 2.50%(1/40); there were 3 cases of drowsiness, 2 cases of dizziness and 1 case of abdominal pain in the group A, the total incidence of adverse reactions was 15.00%(6/40); the total incidence of adverse reactions between the two groups was significantly different(x^2=3.914, P<0.05). Conclusion Salmeterol fluticasone in combination with montelukast sodium has obvious effect in the treatment of acute attack infantile asthma, which is clinically feasible.