盐酸氨溴索与阿奇霉素联合治疗小儿支原体肺炎合并急性支气管炎的临床效果

Effect of ambroxol hydrochloride combined with azithromycin in the treatment of mycoplasma pneumonia combined with acute bronchitis in children

目的研究盐酸氨溴索与阿奇霉素联合治疗小儿支原体肺炎合并急性支气管炎的临床效果。方法选取90例支原体肺炎合并急性支气管炎患儿,根据治疗方式划分为研究组和对照组,每组45例。对照组选用阿奇霉素治疗,研究组选用盐酸氨溴索与阿奇霉素联合治疗。对比两组降钙素原(PCT)、γ-干扰素(IFN-γ)、血清超敏C-反应蛋白(hsCRP)、不良反应发生率及治疗总有效率。结果治疗后,两组患儿PCT、IFN-γ、hsCRP水平均优于治疗前(P<0.05);研究组PCT、IFN-γ、hsCRP水平显著优于对照组(P<0.05);两组患儿不良反应总发生率无显著差异(P>0.05);研究组治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。结论盐酸氨溴索与阿奇霉素联合应用于小儿支原体肺炎合并急性支气管炎治疗的效果显著,值得推广运用。

Objective To study the effect of ambroxol hydrochloride combined with azithromycin in the treatment of mycoplasma pneumonia combined with acute bronchitis in children. Methods Ninety cases of mycoplasma pneumoniae combined with acute bronchitis were selected, and divided into study group and control group according to the treatment method, with 45 cases in each group. The control group was treated with azithromycin, and the study group was given ambroxol hydrochloride and azithromycin. Calcitonin(PCT), interferon gamma(IFN-γ), serum hypersensitivity C-reactive protein(hsCRP), the incidence of adverse reactions and the total effective rate of treatment were compared between the two groups. Results After treatment, the PCT, IFN-γ, hsCRP levels of the two groups were better than those before treatment(P<0.05), the PCT, IFN-γ, hsCRP levels of the study group were significantly better than those of the control group(P<0.05). The total incidence of adverse reactions of both groups had no significant difference(P>0.05), the total effective rate of treatment in the study group was higher than that in the control group, the difference was statistically significant(P<0.05). Conclusion The ambroxol hydrochloride and azithromycin on mycoplasma pneumonia in children with acute bronchitis has remarkable treatment effect, which is worthy of promotion and use.