银川市中老年空腹血糖受损患者神经肽Y基因单核苷酸多样性表达

Single nucleotide polymorphism of neuropeptide Y gene in middle and old age patients with impaired fasting blood glucose in Yinchuan City

目的研究宁夏银川市中老年空腹血糖受损患者神经肽Y(NPY)基因单核苷酸多态性(SNP rs16147)表达。方法调查289名宁夏银川市40岁以上中老年人,通过实验室检查获取血脂、血糖等指标;检测SNP rs16147位点基因型及等位基因频率分布情况,并对正常及空腹血糖受损(IFG)者检测结果做对比分析。结果正常组和IFG组NPY基因SNP rs16147的基因型频率比较,差异显著(P<0.05)。结论空腹血糖受损患者rs16147位点的AA基因型突变率高于正常人。

Objective To investigate the single nucleotide polymorphisms(SNP rs16147)of the neuropeptide Y(NPY)gene in normal middle and old age patients with impaired fasting blood glucose in Yinchuan.Methods A total of 289 people who were over 40 years old in Yinchuan were selected,and the blood lipids,blood glucose were tested through laboratory examination,and the genotype and SNP rs16147 allele frequency were detected,the test results of normal and impaired fasting blood glucose(IFG)patients were compared.Results The genotype frequency of the NYP gene SNP rs16147 in the normal group and IFG group were statistically different(P<0.05).Conclusion The mutation rate of AA genotype at rs16147 in patients with impaired fasting blood glucose is higher than that of the normal subjects.