股骨头坏死的精准医疗:概念与模式

Precision medicine of osteonecrosis of the femoral head: concepts and patterns

背景:近年来,精准医疗已经成为当今医学界的热门话题,精准医疗在股骨头坏死中的应用也越来越广泛。目的:总结目前精准医疗在股骨头坏死中的研究现状及进展。方法:以"精准医疗,股骨头坏死,3D打印,计算机辅助导航,微创,基因"为中文检索词,以"precision medicine,osteonecrosis of the femoral head,3D printing,computer assisted navigation,minimal invasive,gene"为英文检索词,在中国知网和Pub Med数据库检索近10年国内外关于精准医疗在股骨头坏死中应用的相关文献。结果与结论:(1)在股骨头坏死的防治研究中,3D打印技术、计算机辅助导航技术、精准微创骨科技术、基因研究及治疗等技术正是实现精准化、个性化医疗的有效手段;(2)精准医疗这一新的医学模式的出现,丰富了股骨头坏死的治疗手段,提高了股骨头坏死的治疗效果,给广大患者带来了新的曙光,给从事股骨头坏死临床与基础研究的医学工作者、科研人员提供了新的思路和启发。

BACKGROUND:In recent years,precision medicine has become a hot topic in the medical field.The application of precision medicine to osteonecrosis of the femoral head is wider than before.OBJECTIVE:To summarize the current status and progress of precision medicine to osteonecrosis of the femoral head.METHODS:A computer-based search of PubMed and CNKI databases was performed for literatures about application and prospect of precision medicine for osteonecrosis of the femoral head in and outside China published within the past 10 years using the keywords of“precision medicine,osteonecrosis of the femoral head,three dimensional(3D)printing,computer assisted navigation,minimal invasive,gene”in English and Chinese.RESULTS AND CONCLUSION:(1)In the study on the prevention and treatment of osteonecrosis of the femoral head,3D printing technology,computer assisted navigation technology,precision minimally invasive orthopedic technology,research and treatment of gene are four effective ways to achieve precise and personalized healthcare.(2)The appearance of precision medicine,a novel medicinal model,enriches the treatment of osteonecrosis of the femoral head and enhances the curative efficacy of the disease.It brings the new dawn to the patient and provides some new clues for medical workers and researchers engaged in the clinical and basic researches of osteonecrosis of the femoral head.