冠心病心绞痛患者体内纤溶系统的变化及其临床意义

Fibrinolytic System Changes of Angina Pectoris Patients and its Clinical Significance

目的分析冠心病心绞痛患者体内纤溶系统的变化及临床意义。方法抽取我院于2016年3月—2017年9月收治的63例冠心病心绞痛患者为研究对象(63例纳入观察组)。根据患者的心绞痛类型将其分为A组(稳定性心绞痛,33例)、B组(不稳定性心绞痛,30例)。另选同期于我院接受健康体检的30例体检者纳入对照组。以CA-1500型号血凝仪检测所有患者、体检者的纤溶系统指标(PAI-1、t-PA、FIB)。结果观察组PAI-1、FIB均高于对照组,差异具有统计学意义(P<0.05);A组患者PAI-1指标、FIB指标低于B组,A组t-PA高于B组,组间数据对比,差异有统计学意义(P<0.05)。结论冠心病心绞痛患者存在继发性纤溶活性增强,提示冠心病的发生、发展与纤溶系统变化有关。

Objective To analyze fibrinolysis system changes of angina pectoris patients and its clinical significance.Methods 63 cases of angina pectoris in our hospital from March 2016 to September 2017 were selected as the subjects(63 cases were included in the observation group).According to the type of angina pectoris,the patients were divided into A group(stable angina pectoris,33 cases),B group(unstable angina pectoris,30 cases).In the same period,30 cases of physical examination in our hospital were included in the control group.The fibrinolysis system index(PAI-1,t-PA,FIB)of all patients and physical examiners was detected by CA-1500 type hemagglutinin.Results The PAI-1 and FIB in the observation group were all higher than those in the control group,the difference was statistically significant(P<0.05).The PAI-1 and FIB indexes in the A group were significantly lower than those in the B group,and the t-PA in A group was significantly higher than that in the B group,and the difference between the groups was statistically significant(P<0.05).Conclusion There is a secondary fibrinolytic activity in patients with angina pectoris,which suggests that the occurrence and development of coronary heart disease are related to changes in fibrinolysis system.