血清同型半胱氨酸在心肌梗死介入治疗中的临床应用

The Clinical Application of Homocysteine in the Interventional Treatment of Myocardial Infarction

目的探讨血清同型半胱氨酸(homocysteine,Hey)在心肌梗死介入治疗中的临床意义。方法选择2014年6月~2016年1月因急性心肌梗死在本院进行介入治疗的56例患者为治疗组,检测治疗前后高脂血症及血清Hey等指标,并与60例健康者(对照组)进行比较。结果治疗组术前的血压、体重指数(BMI)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(LDL-C)、低密度脂蛋白胆固醇(HDL-C)、血糖及Hcy均高于对照组,差异有统计学意义(P<0.05);治疗组术后Hcy水平低于术前Hcy水平,但高于对照组,差异有统计学意义(P<0.05);多因素Logistic回归分析结果显示血清Hcy是引发AMI的独立危险因素。结论血清同型半胱氨酸在心肌梗死介入治疗后水平下降,与冠心病严重程度相关,有助于了解心肌梗死的病情及预后。

Objective To investigate the clinical application of homocysteine in the interventional treatment of myocardial infarction.Method 156 patients cured in our hospital treated by percutaneous coronary intervention with acute myocardial infarction from 2 0 1 4 June to 2 0 1 6 January were chosen as the treatment group,before and after treatment hyperlipidemia,homocysteine and other indicators were detected and compared with 6 0 healthy persons(the control group).Result The levels of blood pressure、BMI、TG、TC、LDL-C、HDL-C、GLU and Hcy in the treatment group before the operation were higher than the control group,the difference was statistically significant(P<0.05);The levels of Hcy in the treatment group after the operation were lower than before the operation,but higher than the control group,the difference was statistically significant(P<0.05);multivariate Logistic regression analysis showed that Hcy was an independent risk factor for AMI.Conclusion The Hcy level decreased after acute myocardial infarction PCI,is related to the severity of coronary heart disease,it is helpful to understand the condition and prognosis of myocardial infarction.