葡萄膜黑色素瘤的药物治疗研究现状

Research advances in the treatment for uveal melanoma

葡萄膜黑色素瘤(uveal melanoma,UM)是成人眼内最常见的恶性肿瘤,虽然近30a来涌现出许多局部治疗方法,但患者的生存率一直无明显改善,主要原因是缺乏UM的治疗药物,尤其是抑制转移的药物。国外学者针对UM的药物治疗已经开展了大量的临床试验,我国目前仍然采用传统的眼球摘除术治疗UM,缺乏相应的临床药物研究。本文对国内外开展的UM临床药物试验展开综述,以期为眼科医师或肿瘤科医师提供治疗UM的新思路。

Uveal melanoma(UM)is the most common primary intraocular malignancy in adults.Despite the availability of local treatment modalities,the survival rates of patients with UM have not improved in 30 years.And the main reason is lack of therapeutic drugs for UM,especially agents that inhibit tumor metastasis.Foreign researchers have carried out extensive clinical trials on the agents,but traditional ocular enucleation has been performed for the treatment of UM without any clinical drug tests in China.This paper will give a review on these clinical trials abroad,hoping to provide insight in the treatment of UM for domestic ophthalmologists and oncologist.