冠状动脉微循环功能障碍的研究进展

Research Progress of Coronary Microcirculation Dysfunction

临床上发现10%~30%的患者有典型的心绞痛症状,但是冠状动脉造影时常没有明确的冠状动脉狭窄。现认为此类现象是由冠状动脉微循环功能障碍引起的,且发现冠状动脉微循环功能障碍患者的不良心血管事件发生率高。随着人们对冠状动脉微循环功能障碍的重视,逐渐发现了冠状动脉微循环功能障碍的多种发病机制,也提出了多样性的评估诊断方法及药物治疗手段,现就冠状动脉微循环功能障碍的研究进展进行总结,为冠状动脉微循环功能障碍的循证管理策略提供依据。

Angina without significant coronary artery disease(CAD)has substantial morbidity rates and is present in 10%to 30%of patients undergoing invasive coronary angiography.It is believed that,patients with chest pain without obstructive CAD have coronary microvascular dysfunction(CMD).Patients with CMD have a poor prognosis,and increased rates of adverse cardiovascular events.In recent years,CMD is an increasingly recognized condition that multiple techniques have been used to assess microvascular function,and various substances have been studied for the treatment of CMD.The purpose of this article is to summarize the current knowledge and to provide the next steps for developing evidence-based management strategies for CMD.