天然产物及复方药物抗皮肤瘢痕机制的研究进展

Research Progress of Natural Products and Compound Medicines on the Mechanism of Skin Scars Inhibition

增生性瘢痕和瘢痕疙瘩是皮肤组织损伤后创面过度修复产生的一种常见疑难病。一些天然产物及复方药物中具有较好的抗皮肤瘢痕增生的成分。本文从皮肤瘢痕形成过程中的相关细胞成分、生长因子调节、细胞外基质、胶原代谢、微血管构筑、免疫调节等方面和水平综述天然产物及复方药物的作用机制的研究进展。

Hypertrophic scars and keloids are results of over repair of skin wounds.Research on the prevention of skin scars is one of the most potential and indispensable part of trauma research.Some natural products and compound medicines have great effects on scar inhibition.Studying the natural products and compound medicines on the mechanism of skin scars inhibition has great significance for physicians to treat against hypertrophic scars and keloids.This article reviews the progress,development and mechanism of natural products and compound medicines on skin scars inhibition through cellular components,growth factors,extracellular matrix,collagen metabolism,microvascular architecture and immune regulation aspects and levels.