温度和相对湿度对黄芩苷吸湿性的影响和模型拟合研究

Effect of Temperature and Relative Humidity on Water Adsorption and Model Fitting for Baicalin

黄芩苷是从黄芩根部提取的黄酮类化合物,具有抗菌、利尿、抗炎、解痉和抗肿瘤作用,它含有羟基、羧基等极性基团,因此会吸附空气中水蒸气而具有吸湿性。本文研究温度和相对湿度对黄芩苷吸湿性的影响并对其吸湿数据进行模型拟合,结果表明低温和高湿度导致黄芩苷具有较高的平衡吸湿量和较大的吸湿速度;1st Opt软件统计分析得出吸湿动力学双指数模型、吸附等温线Peleg模型拟合效果较好。

Baicalin is a kind of flavonoids and extracted from the roots of Traditional Chinese Medicine Scutellaria baicalensis Georgi.It has antibacterial,diuresis,anti-inflammatory,spasmolysis and antitumor function.However,baicalin has hygroscopicity due to the polar groups of the hydroxyl and the carboxyl,so the objectives of this study were to investigate the effects of temperature and relative humidity on the hygroscopicity characteristics of baicalin,and to develop an adsorption isotherm model.Results showed that low temperature and high relative humidity led to higher equilibrium moisture content for moisture adsorption processes.At higher temperature,the equilibrium moisture content was reached over a shorter time indicating a higher adsorption rate;relative humidity was also positively correlated with the adsorption rate.To fit experimental data results indicated that the double exponential model was the most suitable for fitting the moisture adsorption kinetics curve and the Peleg model was the most suitable for fitting the adsorption isotherm with R 2=0.9984 for baicalin by the 1stOpt statistical analysis software package.