佛山新生儿高胆红素血症的病例分析

Case analysis of neonatal hyperbilirubinemia in Foshan

目的探讨新生儿高胆红素血症的临床处理,及其出生后6 h内的血清总胆红素水平对出生后78 h后发展为显著的高胆红素血症的预后关系,以尽早避免反复高胆红素血症对患儿造成的损伤。方法观察佛山市新生儿反复高胆红素血症100例临床资料,对新生儿高胆红素血症患儿进行蓝光疗法,辅以益生菌和茵栀黄治疗,同时检测其出生后6 h和78 h的血清总胆红素水平并进行t检验、单因素和多因素回归分析。结果 100例新生儿治疗有效率为95%,出生后6 h TSB水平>5.45 mg/dl的新生儿在出生后78 h后发展为显著的高胆红素血症者具有100%的灵敏度和89%(P=0.0001),具有高度统计学意义。结论冷光源蓝光疗法联合口服茵栀黄和益生菌可有效改善黄疸,新生儿出生后6 h的TSB水平>5.5 mg/dl将作为随后发展成为高胆红素血症的危险预测因素。

Objective:To investigate the clinical treatment of hyperbilirubinemia in newborns.To investigate the relationship between serum total bilirubin in 6h after birth and the occurrence of hyperbilirubinemia in 78h after birth,in order to avoid the injury caused by repeated hyperbilirubinemia as early as possible.Methods:The clinical data of 100 cases of recurrent hyperbilirubinemia in newborns in Foshan was analyzed.All of the newborns were treated with blue light therapy and Probiotics and Yinzhihuang oral liquid.The serum total bilirubin was detected in 6h and 78h after birth.Results The effective rate of treatment was 95%.The sensitivity and specificity of serum total bilirubin(>5.45 mg/dl)in 6h after birth of predicting hyperbilirubinemia in 78h after birth was 100%and 89%(P=0.0001).Conclusion:The effect of blue light therapy and Probiotics and Yinzhihuang oral liquid on neonatal hyperbilirubinemia is satisfactory.The serum total bilirubin(>5.45 mg/dl)in 6h after birth can be used as a predictor of the risk of hyperbilirubinemia.