NDST3基因多态性与云南汉族精神分裂症的关联

A Study of Correlation between NDST3 Gene Polymorphism and Schizophrenia Among Han People in Yunnan

目的探讨欧洲人群中检测到的精神分裂症易感基因NDST3的多态性与中国汉族云南地区精神分裂症的关联性.方法采用SNa Pshot技术对云南地区精神分裂症患者(n=364)和正常对照组(n=287)进行SNP位点rs11098403的基因分型;应用阳性和阴性症状量表(PANSS量表)评估精神分裂症患者的精神症状,通过线性回归分析rs11098403多态性与精神分裂症易感性及rs11098403多态性与精神症状的关联.结果 NDST3基因rs11098403位点基因型和等位基因分布频率在病例组和对照组之间差异无统计学意义(P>0.05);也与阳性症状、阴性症状和一般精神病性症状评分无关.结论 NDST3基因SNP rs11098403多态性与云南汉族精神分裂症的遗传易感无关联性.SNP rs11098403多态性与精神分裂症的关联性与欧洲人群的不同.

Objective To investigate the association between rs11098403 of the NDST3 gene and schizophrenia among Han People in Yunnan.Methods A total of 364 Han patients with schizophrenia and 287 healthy Han people were enrolled in our study.SNaP shot was used to detect the genotype of rs11098403.Positive and Negative Symptoms scale(PANSS)was used to assess the symptoms of schizophrenia.Results No differences were found in the genotype and allele distributions of rs11098403 among patients and the control group(>0.05).The allelic frequencies of rs11098403 showed no significant association with positive symptoms,negative symptoms or general symptoms(>0.05).Conclusions Our study indicated that the association between NDST3 gene and schizophrenia might be specific to European population.