精氨酸酶抑制剂与糖尿病血管内皮功能关系的研究进展

Research Progress of the Relationship between Arginase Inhibitors and Diabetic Vascular Endothelial Function

内皮功能紊乱是2型糖尿血管并发症病的主要危险因素,内皮细胞最重要的产物一氧化氮(NO)作为内源性血管舒张因子,在调节血管舒缩方面起关键作用.NO是以L-精氨酸为底物由一氧化氮合酶(eNOS)催化生成的,精氨酸酶可与eNOS竞争它们的共同底物L-精氨酸从而生成鸟氨酸及尿素,使NO的生成减少.就精氨酸酶的作用基础、精氨酸酶抑制剂对糖尿病血管内皮功能的影响作一综述.

Endothelial dysfunction is a major risk factor for vascular complication.Nitric oxide(NO),the most important product of endothelial cells,lays a key role in regulating vasomotor as an endogenous vasodilatation factor.NO is produced by endothelial NO synthase(eNOS)on its substrate L-arginine.Arginase,which metabolizes L-arginine to urea and ornithine,competes directly with eNOS for L-arginine leading to the decrease of NO production.This paper reviews the basic role of arginase,the development of arginase inhibitors and its effects on diabetic vascular complications.