1-(苯氧乙酰基)-3-芳基咪唑啉-2,4-二酮类化合物的合成及除草活性

Synthesis and Herbicidal Activity of 1-Aroxyacetyl-3-arylimidazolidin-2,4-dione Compounds

为了发现新的除草活性化合物,采用活性亚结构拼接法,以3-芳基咪唑啉-2,4-二酮为中间体,设计、合成了12个未见文献报道的1-(苯氧乙酰基)-3-芳基咪唑啉-2,4-二酮类化合物。所有化合物的结构经过~1H NMR、IR验证。初步生物活性测试结果表明,在100 mg/L质量浓度下,大部分目标化合物对油菜和稗草的生长具有良好的抑制作用,其中化合物H3、H5对油菜的抑制率均为100%。

In order to find new herbicidal compound,twelve novel 1-aroxyacetyl-3-arylimidazolidin-2,4-dione compounds were designed and synthesized by substructure combination strategy using 3-arylimidazolidin-2,4-diones as the intermediate.The structures of the target compounds were confirmed by 1H NMR and IR.The preliminary bioassay results showed that most of the target compounds had good inhibition against rape and barnyardgrass at the concentration of 100 mg/L.Especially,compound H3 and H5 showed 100%inhibitory activity against rape.