鼻及鼻窦黏膜黑色素瘤患者临床资料回顾性研究

A retrospective study of patient clinical data with sinus and nasal malignant mucosal melanoma

目的:研究鼻及鼻窦黏膜黑色素瘤(sinus and nasal mucosal melanoma,SNMM)Ⅲ-Ⅳa期[2010年美国AJCC分期(第7次修订版)]的临床及组织病理学特点、手术治疗及辅助治疗对预后的影响因素。方法:本文对2006年至2017年间收治的满足Ⅲ-Ⅳa期鼻及鼻窦黏膜黑色素瘤患者临床资料进行回顾性研究。结果:最终共纳入16例满足条件的鼻及鼻窦黏膜黑色素瘤患者,其中7例男性,9例女性,平均年龄为63.5(35~81)岁,随访时间为23.5(7~76)个月。患者1年生存率为81.25%,3年生存率为18.75%,5年生存率为12.50%。接受术后辅助治疗患者11例,其中,术后辅助放疗5例,术后辅助生物治疗6例。结论:鼻及鼻窦黏膜黑色素瘤恶性度高,预后差,术后复发和转移发生率较高,彻底清除肿瘤病灶的手术联合术后辅助治疗的综合治疗为首选治疗方法。

Objective:To study the clinical and histopathological features,surgical treatment and adjuvant therapy for the prognosis of sinus and nasal mucosal melanoma,stageⅢ-Ⅳa(2010 US AJCC Seventh Revised Edition).Methods:A retrospective study of patients with stageⅢ-V a stage sinus and nasal mucosal melanoma treated in 2006-2017 was conducted.Results:A total of 16 patients with sinus and nasal mucosal melanoma were enrolled,including 7 males and 9 females,with an average age of 63.5(35~81)years old,with a follow-up of 23.5(7~76)months.The first-year survival rate was 81.25%,the third-year survival rate was 18.75%,and the fifth-year survival rate was 12.50%.5 patients received adjuvant radiotherapy and 6 patients received adjuvant biotherapy.Conclusion:Malignant melanoma of nasal sinus and paranasal sinus is of high malignancy,poor prognosis,high recurrence and metastasis,and the comprehensive treatment is the first choice.