乳腺腺样囊性癌临床病理观察

Adenoid cystic carcinoma of breast: A clinicopathological analysis

目的:探讨乳腺腺样囊性癌临床病理学特点、免疫表型及鉴别诊断要点。方法:分析3例乳腺腺样囊性癌的临床特点、病理组织学形态、免疫组化特点,并复习相关文献。结果:3例乳腺腺样囊性癌均为女性,年龄58~80岁。大体上均为境界相对较清楚的肿块。镜下肿瘤形成管状-梁索状、筛状、实体型结构。肿瘤主要由腺上皮、肌上皮、基底样细胞构成,其中腺上皮表达CK7、CK5/6、CD117,肌上皮表达SMA、p63,基底样细胞表达p63、CK5/6、CD117,但均不表达ER、PR、Her-2。3例乳腺腺样囊性癌均行乳腺癌改良根治术,术后随访至今均无复发。结论:乳腺腺样囊性癌是一种少见的乳腺浸润性癌亚型,有其独特的组织形态学特点,预后较好。

Objective:To study the clinicopathological and immunohistochemical features,differential diagnosis of adenoid cystic carcinoma of breast.Methods:3 cases of breast adenoid cystic carcinoma were studied by clinical data,histopathological and immunohistochemical features.Related literatures were reviewed.Results:All 3 cases of adenoid cystic carcinoma of breast were females,age from 58 to 80 years old.All cases were grossly circumscribed and formed tubular-trabecular,cribriform,and solid-basaloid structures microscopy.The tumor typically consisted of a glandular epithelium and myoepithelial-basal cells.All glandular epithelium expressed CK7,CK5/6,CD117,myoepithelium expressed SMA,p63,basal-like cell expressed p63,CK5/6,CD117,all of which were negative for ER,PR,Her-2.3 cases of breast adenoid cystic carcinoma underwent modified radical mastectomy,there were no recurrence after surgery by follow-up.Conclusion:Adenoid cystic carcinoma of the breast is a rare subtype of breast invasive carcinoma,with a unique histopathological characteristics and favorable prognosis.