氯离子通道在胃癌中的研究进展

Advance of chloride ion channels in gastric cancer

胃癌是一种具有高度侵袭性和致命性的恶性肿瘤,其发病率及死亡率呈逐年增高,好发年龄在50岁以上,男女比例约为2∶1。因此明确胃癌的病因与发病机制、寻找早期诊断方法及有效药物靶点显得尤为重要。近年的研究表明,氯离子通道蛋白的异常表达与肿瘤的发生发展密切相关,氯离子通道的主要功能是调节跨上皮转运、膜电位和细胞免疫应答。氯离子通道异常与胃癌的增殖、凋亡、迁移、侵袭密切相关。本文就氯离子通道蛋白CLIC1、TMEM16A和SLC26A9与胃癌的关系进行一综述。

Gastric cancer is a highly aggressive and lethal malignant tumor.Its morbidity and mortality are increasing year by year.The incidence of gastric cancer is over 50 years old.The ratio of male to female is about 2[DK]∶1.Therefore,it is very important to clarify the etiology and pathogenesis of gastric cancer and to find early diagnostic methods and effective drug targets.Recent studies have shown that the abnormal expression of chloride ion channel protein is closely related to the development of tumor.The main function of chloride[KG(-*9]ion channel is to regulate transplastation,membrane potential[KG)]and cellular immune response.The abnormality[KG(*9]of chloride channel is closely related to the[KG)]proliferation,apoptosis,migration and invasion of gastric cancer.This article reviews the relationship between chloride channel proteins CLIC1,TMEM16A and SLC26A9 and gastric cancer.