非小细胞肺癌患者血浆和组织中尾加压素Ⅱ的表达及临床意义

Expressions and Significances of UrotensinⅡ in Plasma and Tissues of Patients with Non-small Cell Lung Cancer

目的检测尾加压素Ⅱ(UⅡ)在非小细胞肺癌(NSCLC)患者手术切除组织及血浆中的表达情况。方法收集2009年1月—2011年1月手术切除的75例NSCLC组织及33例肺炎性假瘤组织,分析UⅡ表达与NSCLC病理类型及TNM临床分期的相关性。测定75例NSCLC、38例肺良性病变、30例健康人血浆中UⅡ含量,分析UⅡ与NSCLC病理类型及有无远处转移的相关性。结果 UⅡ在NSCLC血浆中的表达水平高于肺良性病变组和健康对照组,且UⅡ表达水平与病理类型及有无远处转移有一定的相关性(P<0.05,P<0.01)。UⅡ广泛存在于NSCLC尤其是腺癌细胞的细胞质中,且UⅡ表达与病理类型及TNM临床分期密切相关(P<0.05)。UⅡ在血浆和组织中的表达趋势基本一致。结论 UⅡ在NSCLC尤其是腺癌的侵袭性生长和转移的恶性潜能明显增加,可以作为监测肺腺癌恶性生长的一个分子标志物。

Objective To investigate Urotensin-Ⅱ(UⅡ)expressions in plasma and lung cancer tissues by surgical resection of patients with non-small cell lung cancer(NSCLC).Methods A total of 75 NSCLC tissues and 33 inflammatory pseudotumour tissues in lung by surgical resection during January 2009 and January 2011 were collected,and correlations between UⅡexpression with NSCLC pathological types and TNM stage were analyzed.UⅡcontents in 75 NSCLC tissues,38 benign lesions and 30 healthy plasma samples were detected,and correlations between UⅡcontents with NSCLC pathological types and whether having distant metastasis or not were also analyzed.Results UⅡexpression level in plasma of NSCLC was significantly higher than those in control and benign lesions groups,and plasma UⅡlevel had a certain correlations with pathological types and distant metastasis(P<0.05,P<0.01).UⅡgenerally existed in cytoplasm of NSCLC cells especially in adenocarcinoma cells.There were closely correlations between UⅡexpression with pathological types and TNM stage(P<0.05).UⅡexpressions were basically the same trend in plasma and cancer tissues of NSCLC patients.Conclusion Malignant abilities of UⅡgrowth and metastasis in NSCLC cells increase significantly,and therefore it can be used as a molecular maker to monitoring malignant growth of lung adenocarcinoma.