培美曲塞联合铂类一线药物治疗晚期非鳞型非小细胞癌的疗效观察

Effect observation of pemetrexed combined with platinum on the treatment of patients with advanced non-squamous non-small cell lung cancer

目的探讨培美曲塞联合铂类一线药物在晚期非鳞型非小细胞癌患者中的临床疗效及安全性。方法选取晚期非鳞型非小细胞癌患者74例,观察组39例采用培美曲塞联合顺铂的治疗方案,对照组35例给予顺铂治疗。治疗2个周期后对2组患者治疗效果进行评价,观察患者治疗期间的不良反应与并发症的发生情况。结果观察组患者部分缓解率为38.5%,显著高于对照组20.0%,进展率为7.7%,显著低于对照组17.1%。观察组患者出现恶心呕吐、腹痛腹泻、脱发、神经毒性、血小板减少、白细胞减少、肝功能受损的毒性反应较对照组并无显著差异。结论培美曲塞联合顺铂可在不增加患者化疗不良反应的同时显著提高非鳞型非小细胞型肺癌患者化疗的临床疗效。

Objective To explore the efficacy and safety of pemetrexed combined with platinum in the treatment of patients with advanced non-squamous non-small cell lung cancer.Methods A total of 74 patients with advanced non-squamous non-small cell lung cancer were collected,35 cases in the control group were treated with cisplatin,and 39 cases in observation group was treated with pemetrexed combined with cisplatin.After two cycles of treatment,therapeutic effect,toxic reaction and complications were compared between two groups.Results The partial remission rate of the observation group was 38.5%,which was significantly higher than 20.0%of the control group,and the rate of progress was 7.7%,which was significantly lower than 17.1%of the control group.The adverse reactions and complications such as nausea and vomiting,abdominal pain,diarrhea,alopecia,neurotoxicity,thrombocytopenia,leukocyte reduction and liver function damage showed no significant differences between two groups.Conclusion Pemetrexed combined with cisplatin can significantly improve the clinical efficacy of chemotherapy in patients with non-squamous cell lung cancer without increasing the adverse effects of chemotherapy.