老年功能性便秘应用不同类型通便药物治疗的疗效分析

Effect of different laxative drugs in senile functional constipation

目的探究老年功能性便秘患者选择应用不同类型通便药物进行治疗的临床治疗效果。方法选择老年功能性便秘患者160例,并通过随机样表法分Ⅰ组、Ⅱ组、Ⅲ组与Ⅳ组,各40例,分别应用莫沙必利、莫沙必利联合乳果糖、非比麸联合乳果糖以及莫沙必利,非比麸联合乳果糖治疗,持续治疗30 d,分析治疗后出现排便时间、腹胀、排便不尽、腹痛、粪便性质以及排便频率,以及停药后的复发率等指标。结果治疗前,4组老年功能性便秘患者自主排便频率、排便困难程度以及腹胀腹痛、排便不尽等指标评分差异无统计学意义(P>0.05),治疗后,Ⅳ组有效性明显优于Ⅱ组、Ⅲ组、Ⅰ组。治疗后Ⅰ组、Ⅱ组、Ⅲ组与Ⅳ组停药30 d患者的复发率分别为23.3%、13.4%、10.2%与8.4%,4组老年功能性便秘患者通过单一用药和多种药物联合治疗后,其治疗的有效率分别为60.00%、80.00%、82.50%、87.50%(P<0.05)。结论老年功能性便秘选择不同药物联合治疗可以起到较好的治疗效果,其安全性和有效性能够优于单一药物治疗,值得在临床应用。

Objective To investigate the clinical effect of different laxative drugs for senile patients with functional constipation.Methods A total of 160 elderly patients with functional constipation were randomly divided into four groups:groupⅠ,groupⅡ,groupⅢand groupⅣ,with 40 patients in each group,treated with mosapride,mosapride and lactulose in combination,Bran combined with lactulose and mosapride,Bran combined with lactulose,respectively.Continuous treatment was lasted for 30 days.Defecation time,abdominal distension,endless defecation,abdominal pain,stool quality and defecation frequency,and relapse rate after drug discontinuation after treatment were analyzed.Results Before treatment,there were no significant differences in frequency of spontaneous defecation,difficulty in defecation,abdominal distension and pain,endless defecation in four groups(P>0.05).After treatment,Ⅳgroup had significantly better efficacy thanⅡgroup,Ⅲgroup,andⅠgroup.The relapse rates of groupsⅠ,Ⅱ,ⅢandⅣafter 30 days of treatment were 23.3%,13.4%,10.2%and 8.4%,respectively,and effective rates were 60.00%,80.00%,82.50%and 87.50%,respectively(P<0.05).Conclusion Different drugs combination therapy for elderly functional constipation patients has better therapeutic effect,safety and efficacy.