埃索美拉唑联合泮托拉唑针剂治疗消化性溃疡并发胃出血的临床疗效观察

Clinical effect observation of esomeprazole combined with pantoprazole injection on the treatment of patients with peptic ulcer complicated with gastric hemorrhage

目的分析埃索美拉唑联合泮托拉唑针剂治疗消化性溃疡并发胃出血的临床疗效。方法选取150例消化性溃疡并发胃出血患者,随机分为对照组、研究组各75例。对照组患者采用埃索美拉唑治疗,研究组患者采用埃索美拉唑联合泮托拉唑针剂治疗。比较2组患者疼痛程度、生活质量、出血量及疗效。结果治疗后,2组患者的VAS评分均显著低于治疗前,且研究组显著低于对照组(P<0.05);治疗后,2组患者生活质量SF-36评分均显著高于治疗前,且研究组显著高于对照组(P<0.05);研究组患者的治疗总有效率97.3%,显著高于对照组的82.7%(P<0.05)。结论采用埃索美拉唑联合泮托拉唑针剂治疗能有效抑制患者分泌胃酸,保护患者胃黏膜屏障,降低患者腹部疼痛程度。

Objective To analyze clinical efficacy of esomeprazole combined with pantoprazole injection in the treatment of patients with peptic ulcer complicated with gastric hemorrhage.Methods Totally 150 patients with peptic ulcer complicated with gastric hemorrhage were randomly divided into control group and study group,75 cases in each group.The control group was treated with esomeprazole,and the study group was treated with esomeprazole combined with pantoprazole injection.The degree of pain,quality of life,amount of bleeding and curative effect were observed and compared between the two groups.Results After treatment,VAS score in both groups decreased significantly,and the VAS score of study group was significantly lower than the control group(P<0.05).After treatment,the SF-36 score in both groups increased significantly,and the SF-36 score in study group was significantly higher than the control group(P<0.05).In the study group,the total effective rate of study group was 97.3%,which was significantly higher than 82.7%in the control group(P<0.05).Conclusion Esomeprazole combined with pantoprazole injection can effectively inhibit gastric acid secretion,protect the gastric mucosa alleviate lower abdominal pain.