可调节支具不对称固定建立幼猪无创脊柱侧凸模型

The Establishment of Porcine Scoliosis Model by the Adjustable Brace Asymmetric Tethering

目的建立一种对脊柱结构无创、适合进一步矫形实验研究的脊柱侧凸动物模型.方法设计并制作可调整外固定支具,对6只幼猪行肩胛部及骨盆部支具固定、左侧方适当加压栓系,使脊柱右侧凸.固定术前及术后1、2、3个月摄脊柱正侧位X线片,观察脊柱侧凸的进展情况,测量Cobb角及顶椎旋转情况.结果实验幼猪固定术后1月松解外固定支具后Cobb角为(9.0±1.6)°;术后2月松解外固定支具后Cobb角为(11.8±1.3)°;术后3月取除外固定支具后Cobb角为(21.6±2.4)°;实验中1只幼猪因麻醉意外死亡.结论可调节支具不对称栓系固定法是一种能避免脊柱侧凸结构的损伤、适用于进一步矫形实验研究的脊柱侧凸动物模型的建模方法.

Objective To explore the feasibility of the adjustable brace asymmetric tethering in concave side for establishing a porcine scoliosis model.Methods Six minority piglets(aged 8-10-week-old,weight 8-10 kg)were selected and the adjustable brace asymmetric tethering in concave side were applied during the procedure.Roentgenography was performed before and immediately after the operation,and 1,2 and 3 months after the procedure.Cobb angles were measured based in the plain radiograph.Results A piglet died for narcotic drug overdose and the other 5 pigs succeeded in modeling.The cobb angles were(9.0±1.6)°in one month,(11.8±1.3)°in two months and(21.6±2.4)°in three months after the operation.Conclusion It's is an effective way to establish the porcine model of rapidly progressive structural scoliosis by the adjustable brace asymmetric tethering in concave side.It avoids the damage to the spinal elements and could be an ideal model for further study on corrective techniques.