早期鼻空肠营养支持对重症胰腺炎血感染标志物变化的影响

The Effect of Early Nasal Jejunum Nutrition on the Inflammatory Markers of Severe Acute Pancreatitis

目的观察早期鼻空肠营养对重症胰腺炎患者血感染标志物的影响,探讨早期恢复肠内营养(EN))是否有利于重症胰腺炎的恢复的机理.方法观察对象:玉溪市人民医院重症胰腺炎的患者,接受早期经鼻空肠恢复肠内营养者为实验组,不接受者为随机对照组.(1)分别比较病程中2组间最大和最小血白蛋白(ALB)、降钙素原(PCT)、C-反应蛋白(CRP)、白介素-6(IL-6)以及血淀粉酶(AMY)的差值;(2)比较两组间恢复经口饮食的时间.统计学方法采用t检验.结果 (1)实验组病程中最大和最小的血IL-6变化明显小于对照组;(2)实验组病程中最大和最小的ALB、CRP、PCT及血淀粉酶(AMY)变化与对照组无差异;(3)实验组恢复经口饮食时间明显短于对照组.结论早期鼻空肠营养能减少IL-6的水平,缩短恢复经口进食的时间,有利于重症胰腺炎的恢复.

Objective The present study aims to investigate the effect of the early nasal jejunum nutrition(NJN)on the inflammatory markers of severe acute pancreatitis(SAP)and to research if the NJN improves the recovery of SAP.Method SAP inpatients were observed during 2016.One group who accepted the NJN was experimental group and another group who did not accept the NJN was control group.The difference of serum albumin(ALB),procalcitonin(PCT),C reactive was compared to observe the effect of the early nasal jejunum nutrition(NJN)on the inflammatory markers of severe Acute Pancreatitis protein(CRP),interleukin 6(IL-6)and serumamylase(AMY)between the highest and lowest levels in two group respectively and the time of diet recovery between two groups.Results(1)The difference of interleukin 6(IL-6)between the highest and lowest levels in experimental group was significantly smaller than that of the control group;the difference of ALB,CRP and PCT between the highest and lowest levels in experimental group was not different from the control group;2)The time of diet recovery of experimental group was shorter than that of the control group.Conclusion The early NJN can reduce the IL-6 level and the time of diet recovery,and then,improve the SAP recovery.