CT全脑灌注成像诊断交叉性小脑神经机能联系不能的价值

Study of crossed cerebellar diaschisis with 320-slice whole brain CT perfusion

目的:探讨320排CT全脑灌注成像诊断交叉性小脑神经机能联系不能(CCD)的价值。方法:收集115例经MRI证实的急性及亚急性期单侧幕上新发脑梗死作为实验组,均除外小脑及颅内椎-基底动脉系统血管病变;选择同期无颅内疾病且无神经系统临床症状的志愿者10例作为对照组。2组均在症状稳定期行320排CT全脑灌注扫描,运用平均通过时间(MTT)、达峰时间(TTP)、脑血流量(CBF)、脑血容量(CBV)4个参数评估全脑灌注改变。结果:实验组诊断出45例CCD,且4个参数图谱发现CCD的比率为MTT>TTP>CBF>CBV。对照组两侧小脑半球灌注值差异无统计学意义(P>0.05)。结论:320排CT全脑灌注成像可有效诊断脑梗死后CCD,且MTT对于发现CCD最敏感。

Objective:To investigate the value of 320-detector row whole brain CT perfusion imaging in diagnosing the crossed cerebellar diaschisis(CCD).Methods:Collect 115 unilateral cerebral infarction patients confirmed by MRI as the experimental group,they were all in the acute and subacute phase and cases of the cerebellum and/or vascular lesions of intracranial vertebral-basilar artery system were excepted.Choose 10 cases of volunteers in the same period who were out of intracranial disease or nervous system symptoms as control group.The 320-detector row CT scanner was performed on all the patients during the stable period.Whole-brain CTP parameters were evaluated for cerebral blood flow(CBF),cerebral blood volume(CBV),time to peak(TTP),mean transit time(MTT).Results:45 cases were diagnosed as CCD in the experimental group and the ratio of the CTP map detecting CCD were MTT>TTP>CBF>CBY.In Control group,the perfusion values of the cerebellar hemisphere on both sides have no statistical difference(P>0.05).Conclusions:The 320-detector row CT whole brain perfusion images can effectively evaluate CCD after cerebral farction,and the MTT parameter was found to be the most sensitive for detecting CCD.