幽门螺杆菌根除率非药物影响因素的Logistic回归分析

Logistic regression analysis on non-pharmacological factors of helicobacter pylori eradication

(1)目的分析影响铋剂四联方案幽门螺杆菌(Helicobacter pylori,Hp)根除率的非药物因素。(2)方法收集感染Hp的消化性溃疡或慢性胃炎患者97例,所有患者均接受铋剂四联方案根除治疗14天,疗程结束1月后复查^(14)C呼气试验。将复查结果阳性与阴性患者的临床资料进行比较,分析影响Hp根除率的非药物因素。(3)结果 97例患者中根除成功75例,根除率77.3%。研究发现,体质量指数、疾病类型与Hp根除率密切相关(P<0.05),性别、年龄、烟酒史与Hp根除率无明显相关性(P>0.05)。Logistic回归分析显示消化性溃疡OR值为0.183(95%CI 0.056~0.597),体质量指数OR值为5.838(95%CI 1.838~18.540)。(4)结论消化性溃疡、体质量指数是影响幽门螺杆菌根除率的独立因素。

Objective To analyze the non-pharmacological factors affecting on the efficacy of bismuth quadruple therapy for eradication of Helicobacter pylori(Hp).MethodsA total of 97 Hp-positive patients with peptic ulcer or chronic gastritis were recruited in this study.All patients received bismuth quadruple therapy for 14 days,and reexamined 14 C urea breath test in four weeks after the treatment.The clinical data of the patients with positive and negative results were compared,and then analyze the factors that influence on the eradication of Hp.Results A total of 75 cases were successfully eradicated in 97 patients.The eradication rate was 77.3%.Body mass index(BMI)and disease type were closely related to Hp eradication rate(P<0.05).Gender,age,smoking and alcohol consumption had no significant effect on the eradication rate of Hp(P>0.05).Logistic regression analysis showed that the OR value of the peptic ulcer was 0.183(95%CI 0.056-0.597),and the BMI was 5.838(95%CI 1.838-18.540).Conclusion The peptic ulcer and BMI are the independent factors to affect the eradication rate of Hp.