缺氧与糖、脂肪代谢在类风湿关节炎发病中的作用

Role of hypoxia, glucose metabolism and fat metabolism in pathogenesis of rheumatoid arthritis: an update

类风湿关节炎(rheumatoid arthritis,RA)是一种以关节滑膜慢性炎症为主要特征的自身免疫性疾病。该病致病机制不明,长期以来,RA发病机制的研究集中在炎症及免疫反应方面。近年研究发现,代谢与免疫密切相关。缺氧及糖、脂肪的代谢异常可影响免疫细胞的发育、分化和功能,从而导致自身免疫性疾病的发生。近年来,越来越多的研究关注代谢途径在免疫和RA发病中的作用,以期从不同的角度探讨RA的发病机制并为RA的治疗提供新的思路。本文复习了近年来相关文献,回顾缺氧及糖、脂肪代谢在免疫和RA发病中的作用。

Rheumatoid arthritis(RA)is an autoimmune disease characterized by chronic synovial membrane inflammation.The pathogenesis of RA is unknown,and the related researches mainly focus on inflammation and immune response.Recent researches have found that metabolism is closely related to immunity.Besides,hypoxia and metabolic disorders of glucose and fat can also affect the development,differentiation and function of immune cells,and then lead to occurrence of autoimmune diseases.In recent years,more and more studies have focused on the role of metabolic pathways in the immunity and pathogenesis of RA,in order to explore the pathogenesis of RA from different perspectives and to provide new ideas for the treatment of RA.In this review,we summarized the role of hypoxia,glucose metabolism and fat metabolism in immunity and pathogenesis of RA.