塞来考昔和布洛芬治疗骨关节炎的比较

Celecoxib vs ibuprofen in treating osteoarthritis

目的 :比较塞来考昔和布洛芬治疗骨关节炎的疗效及安全性。方法 :塞来考昔组 34例 ,给予塞来考昔 10 0mg ,po ,bid ;布洛芬组 32例 ,给予布洛芬 30 0mg ,po ,bid ,疗程 4wk。结果 :塞来考昔组的总有效率为 85 % ,布洛芬组为 81% (P >0 .0 5 ) ;2组不良反应发生率分别为 18%和 34% ,2组发生不良反应的病例数差异无显著性。结论 :塞来考昔能改善骨关节炎的症状和体征 ,疗效与布洛芬相近 。

AIM:To compare the therapeutic effects and safety of celecoxib and ibuprofen in treating osteoarthritis. METHODS: Sixty-six patients with osteoarthritis were divided into two groups.Celecoxib group of thirty-four patients received celecoxib 100 mg, po, bid, for 4 wk. Ibuprofen group of thirty-two patients received ibuprofen 300 mg, po, bid, for 4 wk. RESULTS: The total effective rates were 85 % in celecoxib group and 81 % in ibuprofen group(P> 0.05). The adverse reaction rates were 18 % in celecoxib group and 34 % in ibuprofen group(P> 0.05). CONCLUSION: Celecoxib is an effective and safe drug in treating osteoarthritis.