组织工程组织血管化的研究进展

Research Progress of Vascularization Within Engineered Tissues

应用组织工程技术构建组织和器官,是临床治疗组织、器官缺损和功能损伤的潜在途径之一。但是,构建的组织、器官植入体内后不能及时获得血供,导致萎缩并无法发挥功能。我们针对近年来组织工程组织血管化的研究进展,并根据具体策略的不同,将其分为4个部分,包括支架材料的特殊处理、添加血管生成相关细胞、添加血管生成因子或基因修饰和预血管化等策略,并分析各种血管化策略的优势及存在的问题。

The reconstruction of tissue and organ by tissue engineering is one of the potential treatments for the tissue defect and organ failure.The current main problem of tissue engineering is how to build the blood supply timely after engineered tissue implantation to avoid shrinkage or failed tissue function.The recent literature about the vascularization of engineered tissues was extensively reviewed and divided up into four parts:the modification of scaffold,addition of cells,addition of angiogenic factors or gene therapy,in vitro or in vivo prevascularization,according to the difference of vascularization strategies.The advantages and limitations of various kinds of vascularization strategies were analyzed.Furthermore,the future development direction was put forward.