摘要
目的研究氮酮对6-姜酚透皮吸收的影响。方法采用TP-6卧式扩散池进行体外透皮扩散试验。选择离体大鼠皮肤作为渗透屏障,考察不同体积分数乙醇、氮酮对6-姜酚渗透性能的影响。结果 30%乙醇、3%氮酮对6-姜酚均有显著促渗透作用。结论本研究可为含6-姜酚经皮给药系统的制备提供依据。
AIM To study the effect of azone on transdermal absorption of 6-gingerol.METHODS In vitro transdermal diffusion test was performed by TP-6 horizontal diffusion pool.In vitro rat skins were selected as permeation barrier,the effects of different concentrations of ethanol and azone on permeation performance of 6-gingerol were investigated.RESULTS Both 3 0%ethanol and 3%azone contributed to the significant permeation enhancement of 6-gingerol.CONCLUSION This research can provide reference for the preparation of transdermal drug delivery systems containing 6-gingerol.
作者
孙权
李冰
王星
祝妍
王星皓
陈再兴
SUN Quan;LI Bing;WANG Xing;ZHU Yan;WANG Xing-hao;CHEN Zai-xing(School of Pharmacy,China Medical University,Shenyang 110122,China)
出处
《中成药》
CAS
CSCD
北大核心
2018年第3期583-586,共4页
Chinese Traditional Patent Medicine
关键词
氮酮
6-姜酚
透皮吸收
azone
6-gingerol
transdermal absorption