柳杉枝叶化学成分的研究

Chemical constituents from the twigs and leaves of Cryptomeria fortunei

目的研究柳杉Cryptomeria fortunei Hooibrenk ex Otto et Dietr.枝叶的化学成分。方法柳杉枝叶95%乙醇提取物的乙酸乙酯部位采用硅胶、中压液相(MCI)、Sephadex LH-20柱进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到11个化合物,分别鉴定为异海松酸(1)、山达海松酸(2)、乙酰基异柏酸(3)、复瓦杉酸(4)、异柏酸(5)、松叶酸(6)、13-表柏油酸(7)、19-acetylagathadiol(8)、agatadiol(9)、植醇(10)、榄香醇(11)。结论化合物1~10为二萜,化合物11为倍半萜;化合物2、3、6~11为首次从该植物中分离得到。

AIM To study the chemical constituents from the twigs and leaves of Cryptomeria fortunei Hooi-brenk ex Otto et Dietr.METHODS The ethyl acetate fraction of 95%ethanol extract from C.fortunei was isolated and purified by silica,MCI,and Sephadex LH-20 column,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Eleven compounds were isolated and identified as isopimaric acid(1),sandaracopimaric acid(2),acetylisocupressic acid(3),imbricataloic acid(4),isocupressic acid(5),pinifolic acid(6),13-epicupressic acid(7),19-acetylagathadiol(8),agatadiol(9),phytol(10),elemol(11).CONCLUSION Compounds 1-10 are identified as diterpenoids and compound 11 is identified as sesquiterpenoid;Compounds 2,3,6-11 are obtained from this plant for the first time.