摘要
目的探讨他克莫司治疗风湿免疫病患者血液系统异常的疗效、血药浓度、实验室检查指标之间的相关性。方法收集血液系统异常并使用他克莫司治疗的57例住院患者的基本信息,利用Stata软件统计分析用药前后实验室指标变化、血药浓度与实验室指标的相关性等。结果用药后与用药前比较,红细胞沉降率、白细胞计数、血红蛋白、血小板计数、红细胞压积的差异有统计学意义,且他克莫司血药浓度与三酰甘油水平、红细胞压积呈正相关。结论他克莫司治疗风湿免疫病累及血液系统的患者,能有效改善红细胞沉降率、白细胞计数、血红蛋白、血小板计数、红细胞压积,当血药浓度>3.1 ng·mL^(-1)时,疗效较好,未出现严重不良反应。
Objective To investigate the efficacy of tacrolimus in treating rheumatic immune disease patients with abnormal blood system,and relationship between tacrolimus concentration and laboratory examination indexes.Methods Basic information of 57 rheumatic immune disease patients with abnormal blood system treated with tacrolimus was collected.Laboratory examination indexes and blood concentration of tacrolimus were analyzed by using STATA.Results The levels of ESR,WBC,HB,PLT and HCT were statistically increased after tacrolimus medication.Additionally,the concentration of tacrolimus was positively related to the levels of TRIG and HCT.Conclusion Tacrolimus can effectively improve the levels of ESR,WBC,HB,PLT and HCT in patients with rheumatic immune disease accompanied with abnormal blood system.While tacrolimus concentration was above 3.1 ng·mL-1,the therapeutic effect was better,without serious adverse reactions.
作者
马祝悦
姚瑶
朱怀军
束庆
王红
方芸
MA Zhuyue;YAO Yao;ZHU Huaijun;SHU Qing;WANG Hong;FANG Yun(Drum Tower Clinical College of Integrative Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210008,China;Department of Pharmacy,Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University,Nanjing 210008,China;Department of Rheumatology,Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University,Nanjing 210008,China)
出处
《医药导报》
CAS
北大核心
2018年第4期456-460,共5页
Herald of Medicine
基金
江苏省药学会--夏尔医院药学基金科研课题(S201706)
关键词
他克莫司
风湿免疫病
血液系统
血药浓度
Tacrolimus
Rheumatic immune disease
Blood system
Blood concentration
