慢性乙肝给予干扰素及拉米夫定的干预疗效观察

Intervention Effect of Interferon and Lamivudine in Chronic Hepatitis B Patients

目的:观察慢性乙肝给予干扰素及拉米夫定的干预疗效。方法:对照组1单用拉米夫定,对照组2单用干扰素α-2b,研究组联合应用干扰素α-2b及拉米夫定,对比3组治疗后ALT恢复正常患者比率、HBV-DNA转阴率、HBeAg/抗HBe血清转换率,研究组和对照组1治疗后YMDD变异率。结果:3组治疗后各时段ALT复常率、HBV-DNA转阴率、HBeAg/抗HBe血清转换率均显著上升,3组间ALT复常率无显著差异;研究组各阶段HBV-DNA转阴率及HBeAg/抗HBe血清转换率显著高于对照组1和对照组2,研究组YMDD变异率显著低于对照组1。结论:慢性乙肝给予干扰素及拉米夫定疗效确切。

Objective:To observe the intervention effect of interferon and lamivudine on chronic hepatitis B patients.Methods:Control group 1 was treated with lamivudine alone,control group 2 was treated with interferonα-2b,and the study group was treated with interferon alpha-2b combined with lamivudine.The ratio of ALT recovery to normal patients,HBV-DNA negative rate,HBeAg/anti HBe seroconversion rate were compared among the three groups after treatment,and the YMDD mutation rate in the study group and the control group 1 after treatment was compared.Results:The rates of ALT recurrence,HBV-DNA negative rate and HBeAg/anti HBe seroconversion rate were significantly increased in the three groups after treatment,and there was no significant difference in ALT recurrence rate among the three groups.The negative conversion rate of HBV-DNA and the seroconversion rate of HBeAg/anti HBe in study group were significantly higher than those in control group 1 and control group 2.The mutation rate of YMDD in the study group was significantly lower than that in the control group 1.Conclusion:Interferon and lamivudine int the treatment of chronic hepatitis B with is effective.