早期补充维生素D对早产儿感染性疾病的IL-2、IL-4及免疫球蛋白的影响

The effects of early vitamin D supplementation on IL-2,IL-4 and immunoglobulin in premature infants with infectious diseases

目的探究早期补充维生素D对感染性疾病早产儿白细胞介素(IL)-2、IL-4及免疫球蛋白水平的影响。方法选择该院收治的66例伴有感染性疾病的早产儿为研究对象,按随机数字表法将其分为观察组(37例)和对照组(29例)。对照组给予常规抗感染治疗的同时采用早产儿奶粉进行喂养,观察组则在此基础上于出生后第3天给予维生素D。对比两组早产儿在治疗期间的血清25-(OH)D、IL-2、IL-4水平和免疫球蛋白水平。结果治疗前,两组早产儿的血清25-(OH)D水平及IL-2、IL-4水平比较,差异无统计学意义(P>0.05),治疗4、12d后,观察组的血清25-(OH)D及IL-2水平均明显高于对照组,IL-4水平明显低于对照组,差异有统计学意义(P<0.05)。而两组早产儿的IgA、IgM和IgG水平在治疗前、治疗4、12d后均未见明显差异(P>0.05)。同时在治疗期间,两组早产儿也均未出现明显不良反应,临床用药安全可靠。结论通过早期补充维生素D能够有效提高伴有感染性疾病早产儿的血清25-(OH)D、IL-2水平,降低IL-4水平,在一定程度上提高其免疫抵抗能力,但对其体液免疫中免疫球蛋白水平的影响尚未得到有效证实。

Objective To research the effects of early vitamin D supplementation on interleukin-2(IL-2),IL-4 and immunoglobulin in premature infants with infectious diseases.Methods A total of 66 patients with infectious diseases in our hospital were selected for this study.According to the random number table method,they were divided into the observation group(37 cases)and the control group(29 cases).Patients in the control group were given conventional anti infection treatment while feeding powdered formulas,on this basis,patients in the observation group were given vitamin D from the third day after birth.Compared the serum levels of 25-(OH)D,IL-2,IL-4 and immunoglobulin between the two groups during the treatment period.Results Before treatment,there were no significant differences in serum 25-(OH)D and IL-2,IL-4 levels between the two groups(P>0.05).After the treatment of 4 d and 12 d,the serum levels of 25-(OH)D and IL-2,in the observation group were significantly higher than those in the control group,and the IL-4 was significantly lower than that in the control group,the difference was statistically significant(P<0.05).There were no significant differences in IgA,IgM and IgG levels between the two groups of preterm infants before treatment and after the treatment of 4 d and 12 d(P>0.05).At the same time,the premature infants in two groups also did not appear obvious adverse reactions during the treatment period,the clinical medication was safe and reliable.Conclusion For premature infants with infectious diseases,early vitamin D supplementation could effectively improve the levels of serum 25-(OH)D and IL-2,reduce the level of IL-4,so that the immune resistance has been significantly improved,to ensure the clinical efficacy of anti infective treatment is very favorable.The early vitamin D supplementation on the humoral immune globulin level has not been effectively confirmed.