血清降钙素原与B型尿钠肽在感染性休克患者体液复苏治疗前后的检测意义

Detection of serum procalcitonin and B-type natriuretic peptide before and after fluid resuscitation in patients with septic shock

目的探索监测感染性休克患者体液复苏治疗前后血清降钙素原(PCT)与B型尿钠肽(BNP)的临床意义。方法选取2015年1-12月该院急诊科收治的62例感染性休克患者作为研究对象,监测并记录患者的动脉血气、24h累计复苏液体总量及复苏达标时间,检测患者的血清PCT和BNP水平。结果 62例患者的体液复苏治疗过程,患者的24h内复苏液体量为(7 899.31±1 337.64)mL,复苏达标时间为(19.07±5.64)h。治疗前后pH、Na^+及Cl^-、PCT及BNP值有明显差别,差异均有统计学意义(P<0.05)。复苏24h血清PCT水平与累计复苏液体总量之间呈负相关(r=-0.956,P<0.05)。结论感染性休克患者血清BNP与PCT的改变水平与病情密切相关,感染性休克患者的血清PCT及BNP指标可以作为休克治疗的效果进行监测。

Objective To investigate the clinical significance of serum procalcitonin(PCT)and B-type natriuretic peptide(BNP)before and after fluid resuscitation in patients with septic shock.Methods A total of 62 patients with septic shock were selected from January to December in 2015.The patients with arterial blood gas,24 hours of cumulative resuscitation fluid and the time of resuscitation were monitored and recorded.PCT and BNP levels were detected.Results The resuscitation fluid was(7 899.31±1 337.64)mL and the time of resuscitation was(19.07±5.64)h in the treatment of body fluid resuscitation in 62 patients.There were significant differences in pH,Na+,Cl-,PCT and BNP values before and after treatment,the differences were statistical significant(P<0.05).There was a negative correlation between serum PCT and 24%cumulative serum(r=-0.956,P<0.05).Conclusion The levels of serum BNP and PCT in patients with septic shock were closely related to the disease,and can be used to monitor the therapeutic efficacy in patients with septic shock.