中药有效成分丹参酮ⅡA、三七总苷与阿司匹林抗结直肠癌机制的研究现状及展望

Research Status and Prospect of Tanshinone ⅡA, Panax Notoginseng Saponins and Aspirin on Anti-colorectal Cancer

结直肠癌是消化系统最常见的恶性肿瘤之一,并且其发病率呈逐渐升高的趋势。大量研究发现阿司匹林具有降低结直肠癌发生率的可能,而最新研究发现在具有活血化瘀的中药丹参及三七的提取物丹参酮ⅡA及三七总苷也发现了同样的疗效,因此本文就阿司匹林、丹参酮ⅡA及三七总苷抗结直肠癌的机制研究作一综述,以期为其下阶段研究和开发提供参考。

Colorectal cancer is one of the most common malignant tumors in digestive system,and the incidence is gradually increasing in recent years.A number of studies have found that aspirin can reduce the incidence of colorectal cancer,and the new study found the extract from tanshinone IIA and panax notoginseng has the same effect,therefore the mechanism of aspirin,tanshinone IIA and saponins of panax notoginsen anti colorectal cancer were reviewed,in order to provide a reference for the next phase of research and development.