血清PRO-BNP水平与子痫前期围生期结局关系的回顾性研究

A Retrospective Study on Serum PRO-BNP for Evaluating the Perinatal Outcome of Pre-Eclampsia

目的:回顾性分析B型脑利钠肽前体(pro B-type natriuretic peptide,PRO-BNP)水平预测子痫前期患者母婴预后的价值。方法:采用荧光免疫法测定111例子痫前期孕妇PRO-BNP水平,根据检测水平分为PRO-BNP正常组(85例)和PRO-BNP异常组(26例),随访至分娩,比较2组母婴预后的差异。结果:PROBNP异常组期待治疗者明显减少,2组比较差异有统计学意义(7.7%vs.36.5%,χ~2=7.893,P=0.005)。2组孕妇尿蛋白异常情况、胸水发生率比较,差异有统计学意义(均P<0.05)。2组胎儿窘迫、早产儿和新生儿转儿科发生率、新生儿出生体质量及Apgar评分比较,差异无统计学意义(均P>0.05)。结论:单一血清PRO-BNP水平与子痫前期患者脏器损伤严重性有一定关系,但与新生儿预后无明显关系。

Objective:To explore the application of serum pro-B-type natriuretic peptide(PRO-BNP)in pre-eclampsia patients as a potential predictor of maternal and fetal outcomes.Methods:A total of 111 pre-eclampsia women were enrolled in this retrospective study.The level of serum PRO-BNP was measured by immunofluorescence.According to the levels of PRO-BNP,patients were divided into two groups:the normal group(n=85)and the increased group(n=26).The differences of pregnant outcomes were compared between the two groups.Results:The increased group had the lower rate of the expectant treatment(7.7%vs.36.5%,χ2=7.893,P=0.005)and the higher incidences of proteinuria and pleural effusion when compared with the normal group(both P<0.05).However,there were no significant differences in the fetal distress,the rate of premature infant,the newborn treatment transferred to pediatric department,the body mass of newborn and the Apgar score between the two groups(all P>0.05).Conclusions:The level of serum PRO-BNP was related to the severity of organ injury in those pre-eclampsia women.However,PRO-BNP could not be a predictor of the newborn prognosis.