摘要
系统性硬化症(systemic sclerosis,SSc)是风湿科常见多发病之一,是一种累及全身多系统多器官的结缔组织病(connective tissue disease,CTD)。肺间质病变(interstitial lung disease ILD)是SSc肺脏受累的主要表现,是影响SSc患者死亡的主要原因。本文就SSc合并ILD的遗传易感性、发病机制、相关的生物标志物及诊断研究最新进展进行综述,为提高临床医师对SSc-ILD的认识提供借鉴。
Systemic sclerosis(SSc),one of the most common diseases in rheumatology,is a connective tissue disease(CTD)involving multiple systems and organs.Interstitial lung disease(ILD),a frequent complication of SSc,is the main cause of death in patients with SSc.To improve the awareness of clinicians concerning SSc-ILD,this paper summarizes the recent advances in genetic susceptibility,pathogenesis,related biomarkers and diagnosis of SSc-ILD.
作者
金环
王友莲
JIN Huan;WANG You-lian(Department of Rheumatology and Immunology,Jiangxi Provincial People’s Hospital,Nanchang 330006,China)
出处
《南昌大学学报(医学版)》
CAS
2017年第6期88-93,共6页
Journal of Nanchang University:Medical Sciences
关键词
系统性硬化症
肺间质病变
发病机制
systemic sclerosis
interstitial lung disease
pathogenesis