血清尿酸与脑梗死关系的临床研究

Study on the relationship between serum uric acid and cerebral infarction

目的:通过回顾性分析脑梗死病人血清尿酸(UA)水平,研究血清UA与脑梗死关系。方法:选择脑梗死病人400例,按照不同性别正常血清UA水平,分为低血清UA组、正常血清UA组和高血清UA组,比较各组病人血清UA水平与低密度脂蛋白胆固醇、三酰甘油、总胆固醇、C-反应蛋白关系,并进行组间差异性比较,对不同血清UA组与病人入院时脑梗死神经功能缺损程度关系进行分析。结果:不同血清UA水平的脑梗死病人的三酰甘油、总胆固醇、低密度脂蛋白胆固醇差异均无统计学意义(P>0.05);随着血清UA水平的升高,病人急性期神经功能缺损程度明显降低(P<0.01)。结论:高血清UA水平对脑梗死病人急性期神经功能缺损可能具有保护性作用。

Objective:To analyze the serum level of uric acid(UA)in patients with cerebral infarction,and explore the relationship between the serum UA and cerebral infarction.Methods:Four hundred cerebral infarction patients were divided into the low serum UA group,normal serum UA group and high serum UA group.The serum levels of UA,low density lipoprotein cholesterin,triglyceride,total cholesterol and C-reactive protein were analyzed in three groups.The relationships between the serum levels of UA and degree of nervous functional defect between three groups were compared.Results:The differences of the levels of triglycerides,total cholesterol and low density lipoprotein cholesterin between three group were not statistically significant(P>0.05).With the increasing of the serum level of UA,the degree of nervous functional defect significantly decreased(P<0.01).Conclusions:High serum UA level can play a protection effect on severe neurologic deficit in cerebral infarction patients.