双歧杆菌代谢母乳寡糖机制的研究进展

Advance in Understanding the Mechanism Underlying Bifidobacterial Metabolism of Human Milk Oligosaccharides

母乳寡糖(human milk oligosaccharides,HMO)结构复杂,其能够选择性地促进母乳喂养婴儿肠道中益生菌双歧杆菌的生长。婴儿肠道相关双歧杆菌具有糖苷酶等分子工具,使其能够代谢HMO,且代谢过程具有菌株特异性。本文总结了HMO的结构特点,探讨了婴儿肠道相关双歧杆菌代谢HMO的机制,重点分析了双歧杆菌代谢HMO的种内差异以及代谢过程涉及到的分子工具的研究进展。

Human milk oligosaccharides(HMO)have complex structures and selectively stimulate the growth of probiotic bifidobacteria in the intestine of breast-fed infants.Infant gut-associated bifidobacteria provide molecular tools to metabolize HMO with strain specificity,such as glycosyl hydrolases.This review summarizes the structure of HMO and the mechanism underlying HMO metabolism by infant gut-associated bifidobacteria.The focus of this review is on the current advances in the intraspecific differences in bifidobacterial HMO metabolism and the tools involved in the metabolic process.