加味姜枣饮配合健康宣教防治化疗引起恶心和呕吐的临床观察

Clinical observation on modified Jiangzao decoction combined with health education in prevention and control of chemotherapy-induced nausea and vomiting

目的观察加味姜枣饮配合健康宣教防治化疗引起恶心呕吐的临床疗效。方法选取进行化疗的恶性肿瘤患者60例,随机分为联合组和西药组,各30例。西药组给予托烷司琼止吐,联合组在此基础上服用加味姜枣饮,同时配合健康宣教,比较2组化疗24、72 h内的止吐疗效及治疗期间的不良反应。结果化疗24、72 h内,联合组有效率分别为83.33%和86.67%,西药组分别为70.00%和66.67%,联合组止吐疗效均高于西药组,但差异无统计学意义(P>0.05)。联合组治疗期间不良反应发生率为6.67%,低于西药组的23.33%,但差异无统计学意义(P>0.05)。结论加味姜枣饮配合健康宣教有助于防治化疗所致恶心呕吐,且安全性较高、价格低廉,值得临床推广应用。

Objective To observe the clinical efficacy of modified Jiangzao decoction combined with health education in preventing chemotherapy-induced nausea and vomiting.Methods Totally 60 patients with malignant cancer who underwent chemotherapy were randomly assigned into combined group(n=30)and western medicine group(n=30).The patients in western medicine group were treated with tropisetron for stopping vomiting,while those in combined group were added modified Jiangzao decoction and corresponding health educaiton based on western medicine group.The efficacy of stopping vomiting within 24 h and 72 h and incidence of adverse reactions were compared between two groups.Results Within 24 h and 72 h,the response rates of combined group were 83.33%and 86.67%,and those of western medicine group were 70.00%and 66.67%,respectively.The response rates of combined group were slightly higher than those of western medicine group,but no significant difference was shown(P>0.05).During treatment,the incidence of adverse reactions in combined group(6.67%)was slightly lower than that in western medicine group(23.33%),but no significant difference was shown(P>0.05).Conclusion Modified Jiangzao decoction combined with nursing care is conductive to preventing chemotherapy-induced nausea and vomiting,with good safety and low price,so it deserves to be popularized in clinic.