MiR-155和miR-21在乳腺癌分子亚型诊断中的价值

Value of miR-155 and miR-21 in diagnosis of molecular subtypes of breast cancer

目的探讨miR-21和miR-155在浸润性乳腺癌分子亚型的表达及临床意义。方法收集91例浸润性乳腺癌的临床病理资料,各分子亚型采用RT-PCR方法检测miR-21和miR-155表达量。结果 miR-21在中Luminal A-like型、Luminal B-like型、HER2型和TNBC(triple-negative breast cancer)型的相对表达量分别为0.000±2.238、1.008±1.297、1.627±1.744和0.983±1.630,miR-155的相对表达量分别为-2.313±1.077、-1.022±1.151、-0.051±0.903和-0.728±1.585,Lum inal B-like型、HER2型和TNBC型的m iR-155相对表达量与Luminal A-like型相比较差异有统计学意义(P<0.001)。结论检测浸润性乳腺癌中miR-155表达量有可能成为指导Luminal型乳腺癌患者是否需要行化疗的一种新的手段。

Objective To investigate the expression and clinical significance of miR-21 and miR-155 in the molecular subtypes of invasive breast cancer.Methods The clinicopathologic data of 91 cases of invasive breast cancer were retrieved.The expression levels of miR-21 and miR-155 were detected by qRT-PCR.Results The relative expression levels of miR-21 in luminal A-like,luminal B-like,HER2,and TNBC(triple-negative breast cancer)subtypes of breast cancer were 0.000±2.238,1.008±1.297,1.670±1.774 and 0.983±1.630,respectively,and the relative expression levels of miR-155 were-2.313±1.077,-1.022±1.511,-0.051±0.903 and-0.728±1.585,respectively.There were significant differences in the relative expression levels of miR-155 of luminal B-like,HER2,and TNBC subtypes versus that in luminal A-like subtype(P<0.001).Conclusion Detecting the expression levels of miR-155 in invasive breast cancer may be a new approach for guiding breast cancer patients of luminal type to undertake chemotherapy or not.